When you update the Open edX Platform, you should not change configuration files on a running server. Doing so can result in unpredictable problems.
If you need to change settings on a running server, take the following steps.
Provision a new server that matches the running server.
Make configuration changes on the new server.
Start the new server.
Reroute traffic from the old server to the new server.
Decommission the old server.